Juvéderm F.A.Q.

What is JUVÉDERM®?

JUVÉDERM® is the only HA filler FDA approved* to last up to one year.?†  Ask your physician how you can get long-lasting results with JUVÉDERM®. JUVÉDERM® XC injectable gel is a smooth consistency gel dermal filler that helps to instantly restore your skin’s volume and smooth away facial wrinkles and folds like your “smile lines” or “parentheses” (nasolabial folds) —the creases that run from the bottom of your nose to the corners of your mouth). JUVÉDERM® XC comes in two formulations—JUVÉDERM® Ultra XC and JUVÉDERM® Ultra Plus XC.

* In the United States, JUVÉDERM® is indicated for correction of moderate to severe facial wrinkles and folds (such as nasolabial folds).

This includes all JUVÉDERM® injectable gel formulations. Most subjects acquired optimal correction at initial treatment.

What does JUVÉDERM® XC do?

JUVÉDERM® XC injectable gel temporarily adds volume to facial tissue and restores a smoother appearance to the face.

What is JUVÉDERM® XC indicated for?

JUVÉDERM® Ultra XC and JUVÉDERM® Ultra Plus XC injectable gels are indicated for injection into the mid to deep dermis (below the outer layer of skin) for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases running from the bottom of your nose to the corners of your mouth, aka smile lines or parentheses).

Why does JUVÉDERM® XC come in two formulations?

JUVÉDERM® XC injectable gel is available in two formulations to allow your healthcare professional to tailor treatment to your unique needs. JUVÉDERM® Ultra XC provides versatility in contouring and volumizing facial wrinkles and folds. JUVÉDERM® Ultra Plus XC is a more robust formulation for volumizing and correcting deeper folds and wrinkles.

What makes JUVÉDERM® XC different from other dermal fillers?

Juvéderm® XC is the ONLY hyaluronic acid (HA) filler FDA approved* to last up to 1 year after initial treatment. (See footnotes a, b, c, d). Our unique manufacturing process provides a high concentration of cross-linked hyaluronic acid for long-lasting results. It also works to create a smooth consistency gel that flows easily into the skin and provides a smooth, natural look and feel. All other hyaluronic acid dermal fillers currently on the market are made of granular consistency gels. And, JUVÉDERM® is the first hyaluronic acid dermal filler that has demonstrated its safety and effectiveness in persons of color.

* In the United States, JUVÉDERM® is indicated for correction of moderate to severe facial wrinkles and folds (such as nasolabial folds).

a Most subjects acquired optimal correction at initial treatment. Some subjects required up to 2 touch-ups to achieve optimal correction.

b This includes all JUVÉDERM® injectable gel formulations.

c  JUVÉDERM® Ultra XC Directions for Use; JUVÉDERM® Ultra Plus XC Directions for Use.

Pinsky MA, Thomas JA, Murphy DK, Walker PS; for JUVÉDERM® vs. ZYPLAST® Nasolabial Fold Study Group. Juvederm injectable gel: A multicenter, double-blind, randomized study of safety and effectiveness. Aesthetic Surg J. 2008:28(1):17-23.

What is hyaluronic acid?

Hyaluronic acid is a naturally occurring substance found in all mammals that helps to hydrate and add volume to your skin. In addition to its use as an aesthetic treatment, hyaluronic acid has also been used for more than 20 years for injection into arthritic joints to aid movement as well as for eye surgeries and wound repair.

What is cross-linked hyaluronic acid?

“Uncross-linked” hyaluronic acid in its natural form is in a liquid state. “Cross-linking” is the process through which hyaluronic acid is made into a gel product that can be injected into the skin for long-lasting results.

How is JUVÉDERM® XC injectable gel used in treatment?

Your healthcare provider eases JUVÉDERM® XC injectable gel into the skin using a fine needle to temporarily fill in and augment the treatment area and smooth moderate to severe facial wrinkles and folds such as “smile lines” or “parentheses” (nasolabial folds) and “marionette lines” (oral commissures). JUVÉDERM® XC temporarily adds volume to the skin and may give the appearance of a smoother surface.

What will treatment with JUVÉDERM® XC injectable gel accomplish?

JUVÉDERM® XC injectable gel will help to smooth moderate to severe facial wrinkles and folds. Most patients need one treatment to achieve optimal wrinkle smoothing. And one treatment could smooth your lines and wrinkles for up to 1 year.? d 1, 2 Ask your doctor what you should expect from your initial treatment and when they would recommend rescheduling another appointment.

? Most subjects acquired optimal correction at initial treatment. Some subjects required up to 2 touch-ups to achieve optimal correction.

d This includes all JUVÉDERM® injectable gel formulations.

1. JUVÉDERM® Ultra XC Directions for Use; JUVÉDERM® Ultra Plus XC Directions for Use.

2. Pinsky MA, Thomas JA, Murphy DK, Walker PS; for JUVÉDERM® vs. ZYPLAST® Nasolabial Fold Study Group. Juvederm injectable gel: A multicenter, double-blind, randomized study of safety and effectiveness. Aesthetic Surg J. 2008:28(1):17-23.

Is treatment with JUVÉDERM® XC injectable gel painful?

Injections may cause some discomfort during and after the injection. The smooth consistency gel of JUVÉDERM® XC allows your doctor to administer it easily and smoothly. And, JUVÉDERM® XC is injected directly into the skin using a fine needle to reduce injection discomfort. Additionally, JUVÉDERM® XC is formulated with lidocaine for a more comfortable treatment experience† 1. Your doctor may choose to numb (anesthetize) the treatment area to further minimize discomfort.

Compared to the non-lidocaine JUVÉDERM® formulation.

1. Weinkle SH, Bank DE, Boyd CM, Gold MH, Thomas JA, Murphy DK. A multi-center, double-blind, randomized controlled study of the safety and effectiveness of JUVÉDERM® injectable gel with and without lidocaine. J Cosmet Dermatol. 2009;8(3):205-210. Please see JUVÉDERM® Ultra XC and JUVÉDERM® Ultra Plus XC Patient Safety Information for more information.

How long does treatment usually take?

The injection process generally takes only about 15 minutes. You’ll also need to allow time to consult with your doctor prior to treatment.

What kind of doctor can provide treatment with JUVÉDERM® XC injectable gel?

Any authorized healthcare professional can administer JUVÉDERM® XC injectable gel, but dermatologists, plastic surgeons, ophthalmologists, otolaryngologists (ear, nose, and throat doctors), or physicians specializing in cosmetic procedures are generally more experienced. Click here to book an appointment for Juvederm today.

Does the correction last forever?

No. Correction is temporary; therefore, touch-up injections as well as repeat injections are usually needed to maintain optimal corrections.

What are the possible side effects of JUVÉDERM® XC injectable gel?

Most side effects are mild or moderate in nature, and their duration is short lasting (7 days or less). The most common side effects include, but are not limited to, temporary injections site reactions such as redness, pain/tenderness, firmness, swelling, lumps/bumps, bruising, itching, and discoloration. As with all skin injection procedures there is a risk of infection.

Can people with different skin tones/colors be treated with JUVÉDERM®?

Yes. In fact, JUVÉDERM® injectable gel is the first FDA-approved hyaluronic acid dermal filler that has proven its safety and effectiveness in persons of color. Studies with JUVÉDERM® showed no increased risk of hyperpigmentation or hypertrophic scarring in patients of color.1

1. Grimes PH, Thomas JA, Murphy DK. Safety and effectiveness of hyaluronic acid fillers in skin of color. J Cosmet Dermatol. 2009;8:162-168. Please see JUVÉDERM® Ultra, JUVÉDERM® Ultra Plus, JUVÉDERM® Ultra XC, and JUVÉDERM® Ultra Plus XC Patient Safety Information for more information.

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